Concept

Aldol reaction

Summary
The aldol reaction (aldol addition) is a reaction that combines two carbonyl compounds (aldehydes or ketones) to form a new β-hydroxy carbonyl compound. These products are known as aldols, from the aldehyde + alcohol, a structural motif seen in many of the products. The use of aldehyde in the name comes from its discovery history, where aldehydes were first used in the reaction and not ketones. Aldol structural units are found in many important molecules, whether naturally occurring or synthetic. The aldol reaction is a common means of forming carbon–carbon bonds in organic chemistry. The reaction is used in several industrial syntheses, notably of pentaerythritol, trimethylolpropane, the plasticizer 2-ethylhexanol, and the drug Lipitor (atorvastatin, calcium salt). For many of the commodity applications, the stereochemistry of the aldol reaction is unimportant, but the topic is of intense interest for
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