Concept

Endothelium

Related publications (156)

Angiopoietin-2 regulates gene expression in TIE2-expressing monocytes and augments their inherent proangiogenic functions

TIE2-expressing monocytes/macrophages (TEM) are a highly proangiogenic subset of myeloid cells in tumors. Here, we show that circulating human TEMs are already preprogrammed in the circulation to be more angiogenic and express higher levels of such proangi ...

2010

Photodynamic Therapy Selectively Enhances Liposomal Doxorubicin Uptake in Sarcoma Tumors to Rodent Lungs

Hubert van den Bergh, Georges Wagnières, Elodie Debefve, Laurent Décosterd

Background: In specific conditions, photodynamic therapy (PDT) can enhance the distribution of macromolecules across the endothelial barrier in solid tumors. It was recently postulated that tumor neovessels were more responsive to PDT than the normal vascu ...

Wiley-Blackwell2010

Radiotherapy Suppresses Angiogenesis in Mice through TGF-beta RI/ALK5-Dependent Inhibition of Endothelial Cell Sprouting

Natsuko Imaizumi

Background: Radiotherapy is widely used to treat cancer. While rapidly dividing cancer cells are naturally considered the main target of radiotherapy, emerging evidence indicates that radiotherapy also affects endothelial cell functions, and possibly also ...

Public Library of Science2010

Reduced cyclic stretch, endothelial dysfunction, and oxidative stress: an ex vivo model

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Paolo Silacci, Tyler Nerton Thacher, Veronica Gambillara

The objective of this study was to investigate whether reduction of cyclic circumferential stretch will impair endothelial function and elevate basal levels of oxidative stress, both known risk factors linked to cardiovascular disease. ...

2009

Differential effects of reduced cyclic stretch and perturbed shear stress within the arterial wall

Tyler Nerton Thacher

Due to the pulsatile nature of blood flow, arteries are constantly exposed to dynamic mechanical forces; the pulsatility continuously stretches the vessel wall and the flow creates a frictional force on the interior surface. These stresses, referred to as ...

EPFL2009

A tissue-engineered model of the intestinal lacteal for evaluating lipid transport by lymphatics

Melody Swartz, Sandeep Raghunathan, James Brandon Dixon

Lacteals are the entry point of all dietary lipids into the circulation, yet little is known about the active regulation of lipid uptake by these lymphatic vessels, and there lacks in vitro models to study the lacteal-enterocyte interface. We describe an i ...

Wiley-Blackwell2009

Stem cell-based cardiovascular tissue engineering

Thomas Krähenbühl

Cardiovascular diseases, including myocardial infarction, are the leading cause of death worldwide for both men and women. Current therapies are limited by the restricted intrinsic regeneration capacity of the heart and by the lack of organs for transplant ...

EPFL2009

Autonomous effects of shear stress and cyclic circumferential stretch regarding endothelial dysfunction and oxidative stress: an ex vivo arterial model

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, Paolo Silacci, Tyler Nerton Thacher

Cyclic circumferential stretch and shear stress caused by pulsatile blood flow work in concert, yet are very different stimuli capable of independently mediating endothelial function by modulating eNOS expression, oxidative stress (via production of supero ...

American Soc Mechanical Engineers, Three Park Avenue, New York, Ny 10016-5990 Usa2009

Bioactive Lipids Lysophosphatidic Acid and Sphingosine 1-Phosphate Mediate Breast Cancer Cell Biological Functions Through Distinct Mechanisms

Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are structurally related bioactive lipids with growth factor-like activities. LPA and SIP are naturally produced in vivo by blood platelets upon platelet aggregation and at least in vitro by fib ...

2009

3D multi-chamber fluidic systems for analysis of angiogenesis in biomaterials: development, characterization and applications

Carmen Bonvin

The cellular processes leading to capillary morphogenesis depend on external stimuli, in particular flow and morphogen gradients. Several devices have been designed to study these interactions in vitro. However, most of these devices allow a single experim ...

2009

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