Concept

Hippocampus

Related publications (246)

Temporal Dissociation of Neocortical and Hippocampal Contributions to Mental Time Travel Using Intracranial Recordings in Humans

In mental time travel (MTT) one is "traveling" back-and-forth in time, remembering, and imagining events. Despite intensive research regarding memory processes in the hippocampus, it was only recently shown that the hippocampus plays an essential role in e ...

2018

Neurotrophic-mimetic strategy to rescue synaptic plasticity and cognitive functions in a mouse model of Down syndrome

Diego Ghezzi

Down syndrome (DS) is caused by the triplication of human chromosome 21, and it is the most frequent genetic cause of cognitive disabilities. Although numerous studies have shown that cognitive impairment possibly arises from dysfunction of the hippocampal ...

2018

Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex

Gregor Rainer, Laura Lozano Montes, Nan Zhao

Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully charac ...

2018

RNA velocity of single cells

Gioele La Manno

RNA abundance is a powerful indicator of the state of individual cells. Single-cell RNA sequencing can reveal RNA abundance with high quantitative accuracy, sensitivity and throughput 1 . However, this approach captures only a static snapshot at a point in ...

2018

Cerebral Corpora amylacea are dense membranous labyrinths containing structurally preserved cell organelles

Henning Paul-Julius Stahlberg, Amanda Jennifer Lewis

Corpora amylacea are cell-derived structures that appear physiologically in the aged human brain. While their histological identification is straightforward, their ultrastructural composition and microenvironment at the nanoscale have remained unclear so f ...

Springer Nature2018

Model-based reinforcement learning and navigation in animals and machines

Dane Sterling Corneil

For decades, neuroscientists and psychologists have observed that animal performance on spatial navigation tasks suggests an internal learned map of the environment. More recently, map-based (or model-based) reinforcement learning has become a highly activ ...

EPFL2018

Data-Driven Modeling of Cholinergic Modulation of Neural Microcircuits: Bridging Neurons, Synapses and Network Activity

Henry Markram, Srikanth Ramaswamy, Cristina Colangelo

Neuromodulators, such as acetylcholine (ACh), control information processing in neural microcircuits by regulating neuronal and synaptic physiology. Computational models and simulations enable predictions on the potential role of ACh in reconfiguring netwo ...

2018

Impact of conductance drift on multi-PCM synaptic architectures

Yusuf Leblebici, Irem Boybat Kara, Evangelos Eleftheriou, Abu Sebastian

In-memory computing with nanoscale memristive devices such as phase-change memory (PCM) has emerged as an alternative to conventional von Neumann systems to train deep neural networks (DNN) where a synaptic weight is represented by the device conductance. ...

IEEE2018

Neurotrophic-mimetic strategy to rescue synaptic plasticity and cognitive functions in a mouse model of Down syndrome

Diego Ghezzi

Down syndrome (DS) or trisomy 21 is the most frequent genetic cause of intellectual disability in children and adults. Although numerous studies have shown that cognitive impairment possibly arises from dysfunction of the hippocampal circuit, there has bee ...

2017

Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Diego Ghezzi

Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabili ...

2017

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