Publications related to Malignancy

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Elisa Oricchio, Daniele Tavernari, Mohammad Sadegh Saghafinia, Elena Battistello, Stephanie Jocelyne Sungalee, Franck Claude Raynaud, Giovanni Ciriello, Marco Mina, Titouan Laessle

Cancer evolves through the emergence and selection of molecular alterations. Cancer genome profiling has revealed that specific events are more or less likely to be co-selected, suggesting that the selection of one event depends on the others. However, the ...

Cell Press2017

Microenvironmental regulation of tumour angiogenesis

Michele De Palma, Daniela Biziato

Tumours display considerable variation in the patterning and properties of angiogenic blood vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming of neoplastic tissue is a multidimensional process regulated by cancer cel ...

Nature Publishing Group2017

Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

Georges Wagnières, Matthieu Philippe Emmanuel Zellweger

Photodynamic therapy (PDT) is based on the combined administration of photosensitizing drugs and light to treat a variety of malignant, pre-malignant and also non-malignant diseases. The reactive species resulting from the excitation of the photosensitizer ...

Natl Inst Optoelectronics2016

Compact solid-state CMOS single-photon detector array for in vivo NIR fluorescence lifetime oncology measurements

Edoardo Charbon, Claudio Bruschini, Harald Arjan Robert Homulle, Krisztian Homicsko, François Eric Powolny, Riccardo Sinisi, David Li

In near infrared fluorescence-guided surgical oncology, it is challenging to distinguish healthy from cancerous tissue. One promising research avenue consists in the analysis of the exogenous fluorophores' lifetime, which are however in the (sub-)nanosecon ...

Optical Soc Amer2016

Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance

Paul Joseph Dyson, Mylène Soudani, Tina Riedel

Tetranuclear arene ruthenium complexes of the general formula {Ru-2(p-cymene)(2)(mu(4)-L)}(2)(mu(4)-tpom) (tpom = tetrakis(4-pyridyloxymethylene)methane) were obtained from the corresponding dinuclear arene ruthenium complexes [Ru-2(p-cymene)(2)(m(4) ...

Elsevier Science Sa2016

Axo: Tolerating Delay Faults in Real-Time Systems

Jean-Yves Le Boudec, Simon Bliudze, Wajeb Saab

We address delay faults: faults that cause a software component to take more time for completing an action than a given deadline. Such faults are particularly of interest in real- time mission-critical control applications that use general-purpose computin ...

2016

Injectable cryogel-based whole-cell cancer vaccines

Thomas Michael Braschler, Sidi Ahmed Bencherif

A biomaterial-based vaccination system that uses minimal extracorporeal manipulation could provide in situ enhancement of dendritic cell (DC) numbers, a physical space where DCs interface with transplanted tumour cells, and an immunogenic context. Here we ...

Nature Publishing Group2015

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition

Hubert van den Bergh, Patrycja Nowak-Sliwinska

The angiogenesis inhibitor sunitinib is a tyrosine kinase inhibitor that acts mainly on the VEGF and PDGF pathways. We have previously shown that sunitinib is sequestered in the lysosomes of exposed tumor and endothelial cells. This phenomenon is part of t ...

Nature Publishing Group2015

In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia

Paul Joseph Dyson, Patrycja Nowak-Sliwinska, Catherine Marie Amélie Clavel, Emilia Paunescu

Hyperthermia used as an adjuvant with chemotherapy is highly promising in the treatment of certain cancers. Currently, the small molecule drugs used in combination with hyperthermia were not designed for this application. Herein, we report the evaluation o ...

2015

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Malignancy

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Microenvironmental regulation of tumour angiogenesis

Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers

Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

Compact solid-state CMOS single-photon detector array for in vivo NIR fluorescence lifetime oncology measurements

Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance

Axo: Tolerating Delay Faults in Real-Time Systems

Injectable cryogel-based whole-cell cancer vaccines

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition

In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia

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Chat with Graph Search

Review of the role played by the photosensitizer's photobleaching during photodynamic therapy

Microenvironmental regulation of tumour angiogenesis

Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition

Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies

Cytotoxicity of arene ruthenium metalla-rectangles incorporating bis-pyridyl diimide linkers

Compact solid-state CMOS single-photon detector array for in vivo NIR fluorescence lifetime oncology measurements

Cytotoxic double arene ruthenium metalla-cycles that overcome cisplatin resistance

Axo: Tolerating Delay Faults in Real-Time Systems

Injectable cryogel-based whole-cell cancer vaccines

In vivo evaluation of small-molecule thermoresponsive anticancer drugs potentiated by hyperthermia