Concept
Organ of Corti
Related publications (32)
Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility
Simon Nessim Henein, Charles Baur, Loïc Benoît Tissot-Daguette
Surgeons generally assess the mobility of the ossicle chain by manual palpation using rigid elongated hooks inserted through the ear canal. As the applied forces are in the range of a few grams equivalent force, the measurement remains subjective and its r ...
IEEE2021Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss
Non-Syndromic Hereditary Hearing Loss (NSHHL) is a genetically heterogeneous sensory disorder with about 120 genes already associated. Through exome sequencing (ES) and data aggregation, we identified a family with six affected individuals and one unrelate ...
2021Thermally-Drawn Multi-Electrode Fibers for Bipolar Electrochemistry and Magnified Electrochemical Imaging
Imaging systems using closed bipolar electrode (cBPE) arrays and electrochemiluminescence (ECL) have attracted great attention in recent years as a 2D imaging platform with high spatiotemporal resolution. However, the fabrication techniques for cBPE arrays ...
WILEY2021Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B
Bernard Schneider, Paola Andrea Solanes Vega
Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...
2020Inner ear cellular imaging through scattering bone
Demetri Psaltis, Marilisa Romito
Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...
SPIE-INT SOC OPTICAL ENGINEERING2019Selective femtosecond laser ablation via two-photon fluorescence imaging through a multimode fiber
Demetri Psaltis, Christophe Moser, Damien Claude-Marie Loterie, Eirini Kakkava, Donald Benjaman Conkey, Marilisa Romito
We demonstrate the ability of a multimode fiber probe to provide two-photon fluorescence (TPF) imaging feedback that guides the femtosecond laser ablation (FLA) in biological samples for highly selective modifications. We implement the system through the p ...
OPTICAL SOC AMER2019Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss
Bernard Schneider, Paola Andrea Solanes Vega, Sofia Carmen Suzanne Spataro
Since most dominant human mutations are single nucleotide substitutions(1,2), we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type alleles. However, single nucleotide discrimination can b ...
NATURE PUBLISHING GROUP2019Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids
Frédéric Bruno Martin Gachon, Benjamin Dieter Weger
The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...
CELL PRESS2019Biomedical optical techniques for intracochlear cellular imaging
Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...
EPFL2019Two-photon imaging and selective laser ablation of Cochlea hair cells through a multimode fiber probe
Demetri Psaltis, Christophe Moser, Damien Claude-Marie Loterie, Eirini Kakkava, Marilisa Romito
We demonstrate multimode fiber probe that accomodates dual modality properties for high power ultrashort pulse delivery. A commercially available multimode graded-index (GRIN) fiber is used for two-photon imaging and/or femtosecond laser ablation of Cochle ...
SPIE-INT SOC OPTICAL ENGINEERING2019