Concept
Beta cell
Related publications (159)
SLC25A46 promotes mitochondrial fission and mediates resistance to lipotoxic stress in INS-1E insulin-secreting cells
Loïc Dayon, Andreas Wiederkehr
Glucose sensing in pancreatic D-cells depends on oxidative phosphorylation and mitochondria-derived signals that promote insulin secretion. Using mass spectrometry-based phosphoproteo-mics to search for downstream effectors of glucose-dependent signal tran ...
COMPANY BIOLOGISTS LTD2023Porphyrin metalla-assemblies coupled to cellulose nanocrystals for PDT and imaging applications
Photodynamic therapy (PDT) is an interesting and promising approach to tackle a broad spectrum of cancer. With the combination of a photosensitizer, light and oxygen, PDT achieves a unique selectivity by the production of localized reactive oxygen species ...
WORLD SCIENTIFIC PUBL CO PTE LTD2023The role of nicotinamide riboside metabolism in pancreatic beta cells
Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...
EPFL2022Type 2 diabetes disrupts circadian orchestration of lipid metabolism and membrane fluidity in human pancreatic islets
Jonathan Paz Montoya, Howard Riezman
Recent evidence suggests that circadian clocks ensure temporal orchestration of lipid homeostasis and play a role in pathophysiology of metabolic diseases in humans, including type 2 diabetes (T2D). Nevertheless, circadian regulation of lipid metabolism in ...
PUBLIC LIBRARY SCIENCE2022Islet Encapsulation: New Developments for the Treatment of Type 1 Diabetes
Sandrine Gerber, Qixing Zhang, Yi Wang, Léo Bühler
Islet transplantation is a promising approach for the treatment of type 1 diabetes (T1D). Currently, clinical islet transplantation is limited by allo - and autoimmunity that may cause partial or complete loss of islet function within a short period of tim ...
2022Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity
Johan Auwerx, Kristina Schoonjans
Sirtuin 3 (SIRT3) is a protein deacetylase regulating beta-cell function through inhibiting oxidative stress in obese and diabetic mice, but the detailed mechanism and potential effect of beta-cell-specific SIRT3 on metabolic homeostasis, and its potential ...
AMER DIABETES ASSOC2021Multipotent mesenchymal stromal cells derived from porcine exocrine pancreas improve insulin secretion from juvenile porcine islet cell clusters.
Sandrine Gerber, Luca Szabó, Léo Bühler
Neonatal and juvenile porcine islet cell clusters (ICC) present an unlimited source for islet xenotransplantation to treat type 1 diabetes patients. We isolated ICC from pancreata of 14 days old juvenile piglets and characterized their maturation by immuno ...
2021Cancer Cells Retrace a Stepwise Differentiation Program during Malignant Progression
Douglas Hanahan, Krisztian Homicsko, Mohammad Sadegh Saghafinia, Stephan Wullschleger, Iacovos Michael, Giovanni Ciriello
Pancreatic neuroendocrine tumors (PanNET) comprise two molecular subtypes, relatively benign islet tumors (IT) and invasive, metastasis-like primary (MLP) tumors. Until now, the origin of aggressive MLP tumors has been obscure. Herein, using multi-omics ap ...
AMER ASSOC CANCER RESEARCH2021Augmented mitochondrial energy metabolism is an early response to chronic glucose stress in human pancreatic beta cells
Loïc Dayon, Andreas Wiederkehr, Sofia Moco, Isabelle Chareyron
Aims/hypothesis In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial adaptations in human beta cells durin ...
2020Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic beta-cells
Umberto De Marchi, Guillaume Jacot
Pancreatic beta-cells secrete insulin to lower blood glucose, following a meal. Maintenance of beta-cell function is essential to preventing type 2 diabetes. In pancreatic beta-cells, mitochondrial matrix calcium is an activating signal for insulin secreti ...
2020