Publications related to Extracellular space

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Federico Tortelli, Stéphanie Elisabeth Metzger, Jeffrey James Rice

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

Amer Assoc Advancement Science2014

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Melody Swartz, Witold Waldemar Kilarski, Amanda Waite Lund, Manuel Andreas Fankhauser

Besides being a physical scaffold to maintain tissue morphology, the extracellular matrix (ECM) is actively involved in regulating cell and tissue function during development and organ homeostasis. It does so by acting via biochemical, biomechanical, and b ...

Journal Of Visualized Experiments2014

A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

Alessandra Apicella

Protein misfolding and aggregation in intracellular and extracellular spaces is regarded as a main marker of the presence of degenerative disorders such as amyloidoses. To elucidate the mechanisms of protein misfolding, the interaction of proteins with ino ...

Public Library Science2013

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Boris Hinz, Adriano Garonna, Lysianne Follonier Castella

Myofibroblast contraction is fundamental in the excessive tissue remodeling that is characteristic of fibrotic tissue contractures. Tissue remodeling during development of fibrosis leads to gradually increasing stiffness of the extracellular matrix. We pro ...

Public Library Science2013

The dark sides of capillary morphogenesis gene 2

Françoise Gisou van der Goot Grunberg, Julie Deuquet Ariosa

Capillary morphogenesis gene 2 (CMG2) is a type I membrane protein involved in the homeostasis of the extracellular matrix. While it shares interesting similarities with integrins, its exact molecular role is unknown. The interest and knowledge about CMG2 ...

2012

Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration

Matthias Lütolf, Philipp Sebastian Lienemann, Martin Ehrbar

The regeneration of large bone defects caused by trauma or disease remains a significant clinical problem. Although osteoinductive growth factors such as bone morphogenetic proteins have entered clinics, transplantation of autologous bone remains the gold ...

Elsevier Science Bv2012

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Nicolas Jean Philippe Guex, Julie Deuquet Ariosa, Suzanne Salvi

Hyaline Fibromatosis Syndrome (HIS) is a human genetic disease caused by mutations in the anthrax toxin receptor 2 (or cmg2) gene, which encodes a membrane protein thought to be involved in the homeostasis of the extracellular matrix. Little is known about ...

Wiley Open Access2011

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

Hélène Danielle Perreten Lambert

A tight coupling exists between synaptic activity and glucose utilization by astrocytes. Metabolic cooperation between neurons and astrocytes mediates this coupling. During synaptic activation, glutamate that is released in the synaptic cleft as a neurotra ...

EPFL2011

Measuring In Vivo Protein Half-Life

Didier Trono, Kai Johnsson, Christian Heinis, Isabelle Barde, Sonia Verp, Sandra Eloise Kjeldsen, Karolina Bojkowska, Francesca Santoni de Sio

Protein turnover critically influences many biological functions, yet methods have been lacking to assess this parameter in vivo. Here, we demonstrate how chemical labeling of SNAP-tag fusion proteins can be exploited to measure the half-life of resident i ...

Elsevier2011

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Extracellular space

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

The dark sides of capillary morphogenesis gene 2

Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

Measuring In Vivo Protein Half-Life

Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

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Chat with Graph Search

Biomimetic hydrogels for controlled biomolecule delivery to augment bone regeneration

Lentiviral Transgenesis as a Tool to Study the Role of Uncoupling Protein Isoforms in the Nervous System

Hyaline Fibromatosis Syndrome inducing mutations in the ectodomain of anthrax toxin receptor 2 can be rescued by proteasome inhibitors

Investigation of the role of PICALM on amyloid metabolism in a transgenic mouse model of Alzheimer’s disease

The Mechanical Environment Modulates Intracellular Calcium Oscillation Activities of Myofibroblasts

Long-term Intravital Immunofluorescence Imaging of Tissue Matrix Components with Epifluorescence and Two-photon Microscopy

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

A Hydrophobic Gold Surface Triggers Misfolding and Aggregation of the Amyloidogenic Josephin Domain in Monomeric Form, While Leaving the Oligomers Unaffected

The dark sides of capillary morphogenesis gene 2

Measuring In Vivo Protein Half-Life