Concept

Voltage clamp

Related publications (160)

Three-dimensional Tip Electrode Array Technology for High Resolution Neuro-Electronic System used in Electrophysiological Experiments in-vitro

Alexandre Schmid, Yusuf Leblebici, Neil Joye, Maurizio Lavagnino

A three-dimensional tip electrode array technology for in- vitro electrophysiological experiments is presented. Based on simulation results obtained with a finite element model of the neuron-electrode interface, it has been shown that the electrical coupli ...

2008

Evaluating automated parameter constraining procedures of neuron models by experimental and surrogate data

Henry Markram, Felix Schürmann, Sean Lewis Hill, Thomas Berger, Idan Segev

Neuron models, in particular conductance-based compartmental models, often have numerous parameters that cannot be directly determined experimentally and must be constrained by an optimization procedure. A common practice in evaluating the utility of such ...

2008

Characterization and optimization of liquid electrodes for lateral dielectrophoresis

Philippe Renaud, Thomas Michael Braschler, Harald Van Lintel, Nicolas Demierre, Olof Pontus Linderholm, Urban Seger

Using the concept of insulator-based "electrodeless" dielectrophoresis, we present a novel geometry for shaping electric fields to achieve lateral deviation of particles in liquid flows. The field is generated by lateral planar metal electrodes and is guid ...

2007

Interfacing neurons with carbon nanotubes: electrical signal transfer and synaptic stimulation in cultured brain circuits

Henry Markram, Michele Giugliano, Luca Gambazzi

The unique properties of single-wall carbon nanotubes (SWNTs) and the application of nanotechnology to the nervous system may have a tremendous impact in the future developments of microsystems for neural prosthetics as well as immediate benefits for basic ...

2007

Single-cell RT-PCR, a technique to decipher the electrical, anatomical, and genetic determinants of neuronal diversity

Henry Markram

The patch-clamp technique has allowed detailed studies on the electrical properties of neurons. Dye loading through patch pipettes has allowed characterizing the morphological properties of the neurons. In addition, the patch-clamp technique also allows ha ...

2007

Modulation of proton-induced current fluctuations in the human nicotinic acetylcholine receptor channel

Horst Vogel, Rudolf Hovius, Christophe Danelon, Jörg Grandl

The nicotinic acetylcholine receptor (nAChR) is a ligand-gated ion channel that switches upon activation from a closed state to a full conducting state. We found that the mutation delta S268K, located at 12' position of the second transmembrane domain of t ...

2007

Assembly of microvalves actuated by PZT bender

Jacques Jacot, Thomas Maeder, Yannick Sébastien Fournier, Frank Seigneur

At small sizes, piezoelectric bending actuators are more practical and have more favorable downscaling properties than traditional electromagnets in the field of microfluidics. However, their application is limited by the difficulty of ensuring proper clam ...

2007

Three-dimensional Tip Electrode Array Technology for High Resolution Neuro-Electronic Systems used in Electrophysiological Experiments in-vitro

Alexandre Schmid, Yusuf Leblebici, Neil Joye, Maurizio Lavagnino

A three-dimensional tip electrode array technology for in-vitro electrophysiological experiments is presented. Based on simulation results obtained with a finite element model of the neuron-electrode interface, it has been shown that the electrical couplin ...

2007

PhotoMEA: a new optical biosensor for the study of the functional properties of neuronal networks

Diego Ghezzi

Technological innovations in the fields of biomedical optics and electronics have lead to an extremely high level of miniaturization. These steps opened important perspectives to interface optoelectronic instruments with cellular systems. In this frame, a ...

2006

Predicting spike timing of neocortical pyramidal neurons by simple threshold models

Wulfram Gerstner, Renaud Jolivet

Neurons generate spikes reliably with millisecond precision if driven by a fluctuating current—is it then possible to predict the spike timing knowing the input? We determined parameters of an adapting threshold model using data recorded in vitro from 24 l ...

2006

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