Concept

Arrhythmogenic cardiomyopathy

Related publications (59)

Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway

Background-For reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial. To reconcile this controversy we examined the cardiomyopathy ...

American Heart Association2013

Modeling Atrial Pacing

We present a model-based study of therapeutical approaches to atrial fibrillation with a focus on pacing. After a systematic evaluation of different atrial pacing sites, we selected pacing from the septum area and designed a novel septum pacing protocol fo ...

2013

Embryonic Stem Cell-Based Cardiopatches Improve Cardiac Function in Infarcted Rats

Jeffrey Alan Hubbell

Pluripotent stem cell-seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2-primed cardiac-committed mouse embryonic stem cells, embedded into biodegradab ...

AlphaMed Press2012

Partitioned Solution of Geometrical Multiscale Problems for the Cardiovascular System

Adelmo Cristiano Innocenza Malossi

The aim of this work is the development of a geometrical multiscale framework for the simulation of the human cardiovascular system under either physiological or pathological conditions. More precisely, we devise numerical algorithms for the partitioned so ...

EPFL2012

Ventricle Equilibrium Position in Healthy and Normal Pressure Hydrocephalus Brains Using an Analytical Model

Jean-Marie Drezet, Bryn Andrew Martin, Kamal Shahim

The driving force that causes enlargement of the ventricles remains unclear in case of normal pressure hydrocephalus (NPH). Both healthy and NPH brain conditions are characterized by a low transparenchymal pressure drop, typically 1 mm Hg. The present pape ...

2012

Atrial septal pacing for the termination of atrial fibrillation: study in a biophysical model of human atria

Jean-Marc Vesin, Laurent Renaud Uldry, Lukas Kappenberger

Aims While successful termination by pacing of organized atrial tachycardias has been observed in patients, single site rapid pacing has not yet led to conclusive results for the termination of atrial fibrillation (AF). The purpose of this study was to eva ...

Oxford Univ Press2012

Cardiac and Skeletal Muscle Defects in a Mouse Model of Human Barth Syndrome

Richardus Houtkooper

Barth syndrome is an X-linked genetic disorder caused by mutations in the tafazzin (taz) gene and characterized by dilated cardiomyopathy, exercise intolerance, chronic fatigue, delayed growth, and neutropenia. Tafazzin is a mitochondrial transacylase requ ...

2011

Bio Simulation of Brain Ventricle Dilation in Normal Pressure Hydrocephalus

Kamal Shahim

Hydrocephalus is a brain disease wherein the ventricles dilate and compress the parenchyma towards the skull. It is primarily characterized by the disruption of the cerebrospinal fluid (CSF) flow within the ventricular system. Normal pressure hydrocephalus ...

EPFL2011

Intracardiac organization indices for the monitoring of atrial fibrillation

Sarah Volorio

Atrial fibrillation (AF) is the most common arrhythmia observed in clinical practice. It is responsible for about one third of hospitalizations related to problems of arrhythmia. AF is an important clinical entity due to the increased risk of morbidity and ...

2011

Morphological Study of Intracardiac Signals as a New Tool to Track the Efficiency of Stepwise Ablation of Persistent Atrial Fibrillation

Jean-Marc Vesin, Andréa Buttu, Etienne Pruvot

Intracardiac organization indices such as atrial fibrillation (AF) cycle length (AFCL) have been used to track the efficiency of stepwise catheter ablation (step-CA) of longstanding persistent AF, however with limited success. The morphology of AF activati ...

2011

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