Publications related to Dynein

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

The protein kinase Akt/PKB participates in a great variety of processes, including translation, cell proliferation and survival, as well as malignant transformation and viral infection. In the last few years, novel Akt posttranslational modifications have ...

FRONTIERS MEDIA SA2021

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Georg Fantner, Georgios Hatzopoulos, Tatiana Favez, Oliver Hantschel, Virginie Hamel, Niccolo Banterle, Santiago Harald Andany

Centrioles are evolutionarily conserved multi-protein organelles essential for forming cilia and centrosomes. Centriole biogenesis begins with self-assembly of SAS-6 proteins into 9-fold symmetrical ring polymers, which then stack into a cartwheel that sca ...

NATURE RESEARCH2021

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Henning Paul-Julius Stahlberg, Dongchun Ni

ABCG2 is a multidrug transporter that affects drug pharmacokinetics and contributes to multidrug resistance of cancer cells. In previously reported structures, the reaction cycle was halted by the absence of substrates or ATP, mutation of catalytic residue ...

NATURE RESEARCH2021

Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography

Henning Paul-Julius Stahlberg, Paul Guichard, Virginie Hamel

Centrioles are evolutionarily conserved barrels of microtubule triplets that form the core of the centrosome and the base of the cilium. While the crucial role of the proximal region in centriole biogenesis has been well documented, its native architecture ...

2020

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Hilal Lashuel, Mahmood Haj Yahya

The consistent observation of phosphorylated tau in the pathology of Alzheimer's disease has contributed to the emergence of a model where hyperphosphorylation triggers both tau disassociation from microtubules and its subsequent aggregation. Herein, we ap ...

WILEY-V C H VERLAG GMBH2020

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Yimon Aye, Yi Zhao

Transient associations between numerous organelles-e.g., the endoplasmic reticulum and the mitochondria-forge highly-coordinated, particular environments essential for cross-compartment information flow. Our perspective summarizes chemical-biology tools th ...

ROYAL SOC CHEMISTRY2020

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails

Davide Demurtas, Paul Guichard, Virginie Hamel

Microtubule doublets (MTDs), consisting of an incomplete B-microtubule at the surface of a complete A-microtubule, provide a structural scaffold mediating intraflagellar transport and ciliary beating. Despite the fundamental role of MTDs, the molecular mec ...

AMER ASSOC ADVANCEMENT SCIENCE2019

DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

Paolo De Los Rios, Alessandro Barducci

Cells possess remarkable control of the folding and entanglement topology of long and flexible chromosomal DNA molecules. It is thought that structural maintenance of chromosome (SMC) protein complexes play a crucial role in this, by organizing long DNAs i ...

2019

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Dynein

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism

Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails

DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

Graph Chatbot

Chat with Graph Search

Architecture of the centriole cartwheel‐containing region revealed by cryo‐electron tomography

The phase separation-dependent FUS interactome reveals nuclear and cytoplasmic function of liquid-liquid phase separation

Tuning SAS-6 architecture with monobodies impairs distinct steps of centriole assembly

Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

Akt Is S-Palmitoylated: A New Layer of Regulation for Akt

DNA-segment-capture model for loop extrusion by structural maintenance of chromosome (SMC) protein complexes

Live imaging screen reveals that TYRO3 and GAK ensure accurate spindle positioning in human cells

Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities

Structures of ABCG2 under turnover conditions reveal a key step in the drug transport mechanism