Concept
Asparagine
Related publications (21)
Dissecting the role of the asparagine synthesis in acute liver injury
Amino acids are some of the main building stones of life used in a variety of biological processes, such as protein synthesis, energy metabolism or even as precursors for hormone synthesis. How-ever, some of them also participate and coordinate certain cel ...
EPFL2022Calcium phosphate formation on titanium-based surfaces: bioactivity evaluated by in vitro methods
The prediction of implant behaviors in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. In the field of bone implants, it is commonly accepted that a spontaneous formation of a hydroxyapatite (HA) layer on ...
EPFL2018Experimental and theoretical studies on electropolymerization of polar amino acids on platinum electrode
The anodic oxidation of polar amino acids (L-serine, L-threonine, L-asparagine, and L-glutamine) in aqueous electrolyte on smooth platinum electrode was carried out by cyclic voltammetry coupled to electrochemical quartz crystal microbalance (EQCM). pH (zw ...
Elsevier2017Room temperature decarboxylative cyanation of carboxylic acids using photoredox catalysis and cyanobenziodoxolones: a divergent mechanism compared to alkynylation
Jérôme Waser, Matthew Wodrich, Franck Le Vaillant
The one-step conversion of aliphatic carboxylic acids to the corresponding nitriles has been accomplished via the merger of visible light mediated photoredox and cyanobenziodoxolones (CBX) reagents. The reaction proceeded in high yields with natural and no ...
2017LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer
Johan Auwerx, Kristina Schoonjans, Hadrien Charles Edouard Demagny, Arnaud Comment, Dongryeol Ryu, Xu Wang, Norman Lionel Moullan, Emine Can, Matthias Alexander Sokrates Stein, Maaike Hélène Oosterveer, Pan Xu
Various tumors develop addiction to glutamine to support uncontrolled cell proliferation. Here we identify the nuclear receptor liver receptor homolog 1 (LRH-1) as a key regulator in the process of hepatic tumorigenesis through the coordination of a noncan ...
Cold Spring Harbor Laboratory2016Novel inhibitors of the enzyme activated factor xii (fxiia)
Christian Heinis, Jonas Alfred Karl Wilbs, Vanessa Baeriswyl, Simon Jan Middendorp
The present invention relates to a bicyclic inhibitor of the coagulation enzyme activated factor XII (FXIIa) comprising or consisting of the peptide (X1)(X2)(X3)n(X4)(X5)(X6)m(X7)(X9)l(X10)(X11)(X12)(X13)(X14)k(X15)(X16), wherein (X1) is present or absent ...
2016Cerebral glutamine metabolism under hyperammonemia determined in vivo by localized H-1 and N-15 NMR spectroscopy
Rolf Gruetter, Cristina Ramona Cudalbu, Bernard Lanz, Yves Pilloud, João Miguel das Neves Duarte
Brain glutamine synthetase (GS) is an integral part of the glutamate-glutamine cycle and occurs in the glial compartment. In vivo Magnetic Resonance Spectroscopy (MRS) allows noninvasive measurements of the concentrations and synthesis rates of metabolites ...
Nature Publishing Group2012Peptide Structure and Radical Chemistry in the Gas Phase Revealed by Product Ion Abundance Analysis in Electron Capture and Transfer Dissociation Mass Spectrometry
Peptide and protein ion abundances in mass spectrometry (MS) and tandem mass spectrometry (MS/MS) may provide orthogonal, or complementary, information to their mass measurements. Collision induced dissociation (CID), the most commonly used MS/MS technique ...
EPFL2011Radical Stability Directs Electron Capture and Transfer Dissociation of Beta-Amino Acids in Peptides
Yury Tsybin, Hisham Ben Hamidane, Aleksey Vorobyev
We report on the characteristics of the radical-ion-driven dissociation of a diverse array of beta-amino acids incorporated into alpha-peptides, as probed by tandem electron-capture and electron-transfer dissociation (ECD/ETD) mass spectrometry. The report ...
2010Discrete breathers in protein structures
Recently, using a numerical surface cooling approach, we have shown that highly energetic discrete breathers (DBs) can form in the stiffest parts of nonlinear network models of large protein structures. In the present study, using an analytical approach, w ...
2008