Concept

Sodium-calcium exchanger

Related publications (75)

Ricca's factors as mobile proteinaceous effectors of electrical signaling

Leaf-feeding insects trigger high-amplitude, defense-inducing electrical signals called slow wave potentials (SWPs). These signals are thought to be triggered by the long-distance transport of low molecular mass elicitors termed Ricca's factors. We sought ...

CELL PRESS2023

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses

Maria Reva

A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synap-tic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger rel ...

CELL PRESS2022

Al uptake in calcium silicate hydrate and the effect of alkali hydroxide

Karen Scrivener, Barbara Lothenbach, Yan Yan

The effect of Al and of pH on the structure of calcium silicate hydrate (C-S-H), the most important hydration product in Portland and blended cement, was studied at Ca/Si similar to 1.0. The presence of Al led to higher amounts of secondary phases, larger ...

PERGAMON-ELSEVIER SCIENCE LTD2022

Signal-to-signal neural networks for improved spike estimation from calcium imaging data

Jilt Sebastian

Information processing by a population of neurons is studied using two-photon calcium imaging techniques. A neuronal spike results in an increased intracellular calcium concentration. Fluorescent calcium indicators change their brightness upon a change in ...

PLoS2021

Biophysically detailed mathematical models of multiscale cardiac active mechanics

Alfio Quarteroni, Francesco Regazzoni

Author summary Computer-based numerical simulations of the heart are increasingly assuming a recognized role in the context of computational medicine and cardiology. They are based on mathematical models describing the different physical phenomena occurrin ...

2020

Vascular-targeted low dose photodynamic therapy stabilizes tumor vessels by modulating pericyte contractility

Paul Joseph Dyson, Georges Wagnières, Matthieu Philippe Emmanuel Zellweger, Tina Riedel

Vascular-targeted low-dose photodynamic therapy (L-PDT) was shown to improve chemotherapy distribution in malignant pleural tumors such as malignant pleural mesothelioma (MPM). However, the mechanisms triggered by L-PDT on the tumor vasculature are still d ...

WILEY2019

Structure of a zosuquidar and UIC2-bound human-mouse chimeric ABCB1

Henning Paul-Julius Stahlberg

The multidrug transporter ABCB1 (P-glycoprotein) is an ATP-binding cassette transporter that has a key role in protecting tissues from toxic insult and contributes to multidrug extrusion from cancer cells. Here, we report the near-atomic resolution cryo-EM ...

Proceedings of the National Academy of Sciences2018

Damage of eukaryotic cells by the pore-forming toxin sticholysin II: Consequences of the potassium efflux

Françoise Gisou van der Goot Grunberg, Sylvia Ho

Pore-forming toxins (PFTs) form holes in membranes causing one of the most catastrophic damages to a target cell. Target organisms have evolved a regulated response against PFTs damage including cell membrane repair. This ability of cells strongly depends ...

Elsevier Science Bv2017

Molecular mechanisms governing Ca2+ regulation of evoked and spontaneous release

Ralf Schneggenburger

The relationship between transmitter release evoked by action potentials and spontaneous release has fascinated neuroscientists for half a century, and separate biological roles for spontaneous release are emerging. Nevertheless, separate functions for spo ...

2015

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

Matteo Dal Peraro, Thomas Lemmin, Anna Vestergaard

P4-ATPases (flippases) translocate specific phospholipids such as phosphatidylserine from the exoplasmic leaflet of the cell membrane to the cytosolic leaflet, upholding an essential membrane asymmetry. The mechanism of flipping this giant substrate has re ...

Natl Acad Sciences2014

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