Systems neuroscience

Systems neuroscience is a subdiscipline of neuroscience and systems biology that studies the structure and function of neural circuits and systems. Systems neuroscience encompasses a number of areas of study concerned with how nerve cells behave when connected together to form neural pathways, neural circuits, and larger brain networks. At this level of analysis, neuroscientists study how different neural circuits analyze sensory information, form perceptions of the external world, make decisions, and execute movements. Researchers in systems neuroscience are concerned with the relation between molecular and cellular approaches to understanding brain structure and function, as well as with the study of high-level mental functions such as language, memory, and self-awareness (which are the purview of behavioral and cognitive neuroscience). Systems neuroscientists typically employ techniques for understanding networks of neurons as they are seen to function, by way of electrophysiolog

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Cultural Adaptation, Validation, and Psychometric Description of the Pictorial Empathy Test (PET) in the Spanish Population

Maria del Carmen Sandi Perez

Research in psychology and social neuroscience distinguishes between dispositional and situational empathy for the cognitive and affective aspects of empathy. Yet, the Pictorial Empathy Test (PET) is one of the few brief tests focusing on situational affective empathy. This paper describes the adaptation of PET in a two-stage process, consisting of instrument translation and exploratory analysis of the construct in a university student sample, followed by confirmatory factor analysis and psychometric validation in a general population sample (Study 1, N = 79 and Study 2, N = 580). Our results indicate that the Spanish PET version constitutes a single factor structure with high internal consistency as well as high construct stability across genders and across in-person and online test administration setups. We report satisfactory convergent, discriminant, and nomological validity of the Spanish PET, as reported for the original version, in addition to when explored across new dimensions, like the Interpersonal Reactivity Index or in relation to age and prosocial tendencies. Based on the above, we discuss delineation of the distinct components of emotional empathy as measured by the instrument. The work presented supports the use of the Spanish PET version as a brief screening toot for state affective (emotional) empathy.

HOGREFE PUBLISHING CORP2022

Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill

Elena Beanato, Friedhelm Christoph Hummel, Philipp Johannes Koch, Takuya Morishita, Chang-Hyun Park, Maximilian Jonas Wessel

Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimulation protocols, accounting for motor learning related brain network interactions also, may further enhance effect sizes. Here, we tested different stimulation approaches targeting the cerebro-cerebellar loop. Forty young, healthy participants trained a fine motor skill with concurrent tDCS in four sessions over two days, testing the following conditions: (1) monofocal motorcortical, (2) sham, (3) monofocal cerebellar, or (4) sequential multifocal motorcortico-cerebellar stimulation in a double-blind, parallel design. Skill retention was assessed after circa 10 and 20 days. Furthermore, potential underlying mechanisms were studied, applying paired-pulse transcranial magnetic stimulation and multimodal magnetic resonance imaging-based techniques. Multisession motorcortical stimulation facilitated skill acquisition, when compared with sham. The data failed to reveal beneficial effects of monofocal cerebellar or additive effects of sequential multifocal motorcortico-cerebellar stimulation. Multimodal multiple linear regression modelling identified baseline task performance and structural integrity of the bilateral superior cerebellar peduncle as the most influential predictors for training success. Multisession application of motorcortical tDCS in several daily sessions may further boost motor training efficiency. This has potential implications for future rehabilitation trials.

2021

Resting brain dynamics at different timescales capture distinct aspects of human behavior

Raphaël Pierre Liégeois, Dimitri Nestor Alice Van De Ville

Linking human behavior to resting-state brain function is a central question in systems neuroscience. In particular, the functional timescales at which different types of behavioral factors are encoded remain largely unexplored. The behavioral counterparts of static functional connectivity (FC), at the resolution of several minutes, have been studied but behavioral correlates of dynamic measures of FC at the resolution of a few seconds remain unclear. Here, using resting-state fMRI and 58 phenotypic measures from the Human Connectome Project, we find that dynamic FC captures task-based phenotypes (e.g., processing speed or fluid intelligence scores), whereas self-reported measures (e.g., loneliness or life satisfaction) are equally well explained by static and dynamic FC. Furthermore, behaviorally relevant dynamic FC emerges from the interconnections across all resting-state networks, rather than within or between pairs of networks. Our findings shed new light on the timescales of cognitive processes involved in distinct facets of behavior.

Springer2019

Neuroscience

Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physi

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A neural circuit (also known as a biological neural network BNNs) is a population of neurons interconnected by synapses to carry out a specific function when activated. Multiple neural circuits inte

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Cognitive neuroscience is the scientific field that is concerned with the study of the biological processes and aspects that underlie cognition, with a specific focus on the neural connections in the

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