Concept
Retinal ganglion cell
Related publications (168)
Development of a new visual prosthesis for preclinical studies on artificial vision
Marta Jole Ildelfonsa Airaghi Leccardi
The technological evolution in materials science and microengineering favored the production of advanced visual prostheses useful for fighting blindness and to improve patients quality of life. Visual prostheses aim at replacing lost visual functions by ar ...
EPFL2020In vivo evaluation of gene editing and prosthetic strategies to restore vision in small and large animal models of retinal degeneration
Inherited retinal diseases (IRDs) form a group of diverse disorders that lead to the degeneration of the light-sensing cells of the retina: the photoreceptors. IRDs are among the leading causes of blindness in working-age adults living in industrialized co ...
EPFL2020Object identity determines trans-saccadic integration
Michael Herzog, Leila Drissi Daoudi - Kleinbauer
Humans make two to four rapid eye movements (saccades) per second, which, surprisingly, does not lead to abrupt changes in vision. To the contrary, we perceive a stable world. Hence, an important question is how information is integrated across saccades. T ...
2020Single particle cryo‐EM of the complex between interphotoreceptor retinoid‐binding protein and a monoclonal antibody
Henning Paul-Julius Stahlberg, Andreas Engel
Interphotoreceptor retinoid‐binding protein (IRBP) is a highly expressed protein secreted by rod and cone photoreceptors that has major roles in photoreceptor homeostasis as well as retinoid and polyunsaturated fatty acid transport between the neural retin ...
2020Hydrogel-based milliwell arrays for standardized and scalable retinal organoid cultures
Matthias Lütolf, Nathalie Brandenberg
The development of improved methods to culture retinal organoids is relevant for the investigation of mechanisms of retinal development under pathophysiological conditions, for screening of neuroprotective compounds, and for providing a cellular source for ...
NATURE PUBLISHING GROUP2020Single-cell transcriptional logic of cell-fate specification and axon guidance in early-born retinal neurons
Marion Leleu, Gioele La Manno, Pierre Raymond Fabre
Retinal ganglion cells (RGCs), cone photoreceptors (cones), horizontal cells and amacrine cells are the first classes of neurons produced in the retina. However, an important question is how this diversity of cell states is transcriptionally produced. Here ...
2019Capacitive-like photovoltaic epiretinal stimulation enhances and narrows the network-mediated activity of retinal ganglion cells by recruiting the lateral inhibitory network
Diego Ghezzi, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais
Photovoltaic retinal prostheses theoretically offer the possibility of a standalone high-resolution electrical stimulation of the retina. However, achieving focused epiretinal stimulation is particularly challenging, because of axonal activation and electr ...
2019Object identity determines transsaccadic integration
Very little information is transferred across saccades. It is commonly thought that detailed vision starts mainly anew with each saccade. Here, we show that transsaccadic integration occurs even for very fine grained and unconscious information when object ...
2019Beyond Bouma's window: How to explain global aspects of crowding?
Michael Herzog, Gregory Francis, Adrien Christophe Doerig, Aaron Michael Clarke, Alban Bornet
In crowding, perception of an object deteriorates in the presence of nearby elements. Although crowding is a ubiquitous phenomenon, since elements are rarely seen in isolation, to date there exists no consensus on how to model it. Previous experiments show ...
2019Spatially selective activation of the visual cortex via intraneural stimulation of the optic nerve
Silvestro Micera, Diego Ghezzi, Fiorenzo Artoni, Paola Vagni, Vivien Gaillet, Ariastity Mega Pratiwi, Dario Lipucci Di Paola
Retinal prostheses can restore a functional form of vision in patients affected by dystrophies of the outer retinal layer. Beyond clinical utility, prostheses for the stimulation of the optic nerve, the visual thalamus or the visual cortex could also serve ...
2019