Concept

Placenta praevia

Related publications (13)

Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity

Jeffrey Alan Hubbell, Melody Swartz, Lambert Charles François Potin, Martina Damo, Jun Ishihara, Kazuto Fukunaga

CD40 is an immune costimulatory receptor expressed by antigen-presenting cells. Agonistic anti-CD40 antibodies have demonstrated considerable antitumor effects yet can also elicit serious treatment-related adverse events, such as liver toxicity, including ...

AMER ASSOC CANCER RESEARCH2018

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Jeffrey Alan Hubbell, Melody Swartz, Hans Mattias Larsson, Lambert Charles François Potin, Gabriele Galliverti, Jun Ishihara, Kazuto Fukunaga

Immune checkpoint blockade exhibits considerable antitumor activity, but previous studies have reported instances of severe treatment-related adverse events. We sought to explore local immune checkpoint blockade, with an antibody (Ab) form that would be re ...

Amer Assoc Advancement Science2017

Protein engineering approaches for direct antigen targeting in CD8+ T cell inducing vaccines

Vasiliki Panagiotou

Effective vaccine design and public vaccination programs have led to the eradication of several diseases and protected millions of people from deadly infections. However, intracellular infections remain a challenge and their eradication requires the activa ...

EPFL2016

Conjugates containing sequences from placenta growth factor and their use as components of biomaterials and in medicine

Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez

Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a P1GF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, an ...

2015

The evolution of lncRNA repertoires and expression patterns in tetrapods

Anamaria Necsulea, Magali Soumillon

Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative an ...

Nature Publishing Group2014

Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing

Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Federico Tortelli, Stéphanie Elisabeth Metzger, Jeffrey James Rice

Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...

Amer Assoc Advancement Science2014

Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field

Rolf Gruetter, Nicolas Kunz

Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementat ...

Nature Publishing Group2014

Protective effects of maternal nutritional supplementation with lactoferrin on growth and brain metabolism

Rolf Gruetter, Yohan Van de Looij, Sylviane Métairon

Background:Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementati ...

Nature Publishing Group2014

Proangiogenic Factor PlGF Programs CD11b(+) Myelomonocytes in Breast Cancer during Differentiation of Their Hematopoietic Progenitors

Natsuko Imaizumi, Laura Ciarloni

Tumor-mobilized bone marrow-derived CD11b(+) myeloid cells promote tumor angiogenesis, but how and when these cells acquire proangiogenic properties is not fully elucidated. Here, we show that CD11b(+) myelomonocytic cells develop proangiogenic properties ...

2011

Distinct requirements for Gab1 in Met and EGF receptor signaling in vivo

Gab1 is a multiadaptor protein that has been shown to be required for multiple processes in embryonic development and oncogenic transformation. Gab1 functions by amplifying signal transduction downstream of various receptor tyrosine kinases through recruit ...

2007

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