Concept
Placenta praevia
Related publications (13)
Improving Efficacy and Safety of Agonistic Anti-CD40 Antibody Through Extracellular Matrix Affinity
Jeffrey Alan Hubbell, Melody Swartz, Lambert Charles François Potin, Martina Damo, Jun Ishihara, Kazuto Fukunaga
CD40 is an immune costimulatory receptor expressed by antigen-presenting cells. Agonistic anti-CD40 antibodies have demonstrated considerable antitumor effects yet can also elicit serious treatment-related adverse events, such as liver toxicity, including ...
AMER ASSOC CANCER RESEARCH2018Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events
Jeffrey Alan Hubbell, Melody Swartz, Hans Mattias Larsson, Lambert Charles François Potin, Gabriele Galliverti, Jun Ishihara, Kazuto Fukunaga
Immune checkpoint blockade exhibits considerable antitumor activity, but previous studies have reported instances of severe treatment-related adverse events. We sought to explore local immune checkpoint blockade, with an antibody (Ab) form that would be re ...
Amer Assoc Advancement Science2017Protein engineering approaches for direct antigen targeting in CD8+ T cell inducing vaccines
Effective vaccine design and public vaccination programs have led to the eradication of several diseases and protected millions of people from deadly infections. However, intracellular infections remain a challenge and their eradication requires the activa ...
EPFL2016Conjugates containing sequences from placenta growth factor and their use as components of biomaterials and in medicine
Jeffrey Alan Hubbell, Mikaël Martino, Priscilla Suhasna Maithili Briquez
Embodiments of the invention are described, including materials and methods for making molecules and materials that have a specific binding domain of a P1GF2. Embodiments include, for instance, medicaments, biomaterials, biomolecules, molecular fusions, an ...
2015The evolution of lncRNA repertoires and expression patterns in tetrapods
Anamaria Necsulea, Magali Soumillon
Only a very small fraction of long noncoding RNAs (lncRNAs) are well characterized. The evolutionary history of lncRNAs can provide insights into their functionality, but the absence of lncRNA annotations in non-model organisms has precluded comparative an ...
Nature Publishing Group2014Growth Factors Engineered for Super-Affinity to the Extracellular Matrix Enhance Tissue Healing
Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Witold Waldemar Kilarski, Priscilla Suhasna Maithili Briquez, Esra Güç, Federico Tortelli, Stéphanie Elisabeth Metzger, Jeffrey James Rice
Growth factors (GFs) are critical in tissue repair, but their translation to clinical use has been modest. Physiologically, GF interactions with extracellular matrix (ECM) components facilitate localized and spatially regulated signaling; therefore, we rea ...
Amer Assoc Advancement Science2014Definition and quantification of acute inflammatory white matter injury in the immature brain by MRI/MRS at high magnetic field
Background: Intrauterine growth restriction (IUGR) is a major risk factor for both perinatal and long-term morbidity. Bovine lactoferrin (bLf) is a major milk glycoprotein considered as a pleiotropic functional nutrient. The impact of maternal supplementat ...
Nature Publishing Group2014