Quasi-experimentA quasi-experiment is an empirical interventional study used to estimate the causal impact of an intervention on target population without random assignment. Quasi-experimental research shares similarities with the traditional experimental design or randomized controlled trial, but it specifically lacks the element of random assignment to treatment or control. Instead, quasi-experimental designs typically allow the researcher to control the assignment to the treatment condition, but using some criterion other than random assignment (e.
Treatment and control groupsIn the design of experiments, hypotheses are applied to experimental units in a treatment group. In comparative experiments, members of a control group receive a standard treatment, a placebo, or no treatment at all. There may be more than one treatment group, more than one control group, or both. A placebo control group can be used to support a double-blind study, in which some subjects are given an ineffective treatment (in medical studies typically a sugar pill) to minimize differences in the experiences of subjects in the different groups; this is done in a way that ensures no participant in the experiment (subject or experimenter) knows to which group each subject belongs.
Scientific controlInformal improvements in any process or enquiry have been made by comparison between what was done previously and the new method for thousands of years. A scientific control is a modern formal experiment or observation designed to minimize the effects of variables other than the independent variable (i.e. confounding variables). This increases the reliability of the results, often through a comparison between control measurements and the other measurements. Scientific controls are a part of the scientific method.
Clinical study designClinical study design is the formulation of trials and experiments, as well as observational studies in medical, clinical and other types of research (e.g., epidemiological) involving human beings. The goal of a clinical study is to assess the safety, efficacy, and / or the mechanism of action of an investigational medicinal product (IMP) or procedure, or new drug or device that is in development, but potentially not yet approved by a health authority (e.g. Food and Drug Administration).
RandomizationRandomization is the process of making something random. Randomization is not haphazard; instead, a random process is a sequence of random variables describing a process whose outcomes do not follow a deterministic pattern, but follow an evolution described by probability distributions. For example, a random sample of individuals from a population refers to a sample where every individual has a known probability of being sampled. This would be contrasted with nonprobability sampling where arbitrary individuals are selected.
Protocol (science)In natural and social science research, a protocol is most commonly a predefined procedural method in the design and implementation of an experiment. Protocols are written whenever it is desirable to standardize a laboratory method to ensure successful replication of results by others in the same laboratory or by other laboratories. Additionally, and by extension, protocols have the advantage of facilitating the assessment of experimental results through peer review.
Latin squareIn combinatorics and in experimental design, a Latin square is an n × n array filled with n different symbols, each occurring exactly once in each row and exactly once in each column. An example of a 3×3 Latin square is The name "Latin square" was inspired by mathematical papers by Leonhard Euler (1707–1783), who used Latin characters as symbols, but any set of symbols can be used: in the above example, the alphabetic sequence A, B, C can be replaced by the integer sequence 1, 2, 3. Euler began the general theory of Latin squares.
Interaction (statistics)In statistics, an interaction may arise when considering the relationship among three or more variables, and describes a situation in which the effect of one causal variable on an outcome depends on the state of a second causal variable (that is, when effects of the two causes are not additive). Although commonly thought of in terms of causal relationships, the concept of an interaction can also describe non-causal associations (then also called moderation or effect modification).
Orthogonal arrayIn mathematics, an orthogonal array (more specifically, a fixed-level orthogonal array) is a "table" (array) whose entries come from a fixed finite set of symbols (for example, {1,2,...,v}), arranged in such a way that there is an integer t so that for every selection of t columns of the table, all ordered t-tuples of the symbols, formed by taking the entries in each row restricted to these columns, appear the same number of times. The number t is called the strength of the orthogonal array.
Research designResearch design refers to the overall strategy utilized to carry out research that defines a succinct and logical plan to tackle established research question(s) through the collection, interpretation, analysis, and discussion of data. Incorporated in the design of a research study will depend on the standpoint of the researcher over their beliefs in the nature of knowledge (see epistemology) and reality (see ontology), often shaped by the disciplinary areas the researcher belongs to.
