The muscles of respiration are the muscles that contribute to inhalation and exhalation, by aiding in the expansion and contraction of the thoracic cavity. The diaphragm and, to a lesser extent, the intercostal muscles drive respiration during quiet breathing. The elasticity of these muscles is crucial to the health of the respiratory system and to maximize its functional capabilities. Thoracic diaphragm The diaphragm is the major muscle responsible for breathing. It is a thin, dome-shaped muscle that separates the abdominal cavity from the thoracic cavity. During inhalation, the diaphragm contracts, so that its center moves caudally (downward) and its edges move cranially (upward). This compresses the abdominal cavity, raises the ribs upward and outward and thus expands the thoracic cavity. This expansion draws air into the lungs. When the diaphragm relaxes, elastic recoil of the lungs causes the thoracic cavity to contract, forcing air out of the lungs, and returning to its dome-shape. The diaphragm is also involved in non-respiratory functions, helping to expel vomit, faeces, and urine from the body by increasing intra-abdominal pressure, and preventing acid reflux by exerting pressure on the esophagus as it passes through the esophageal hiatus. Along with the diaphragm, the intercostal muscles are one of the most important groups of respiratory muscles. These muscles are attached between the ribs and are important in manipulating the width of the rib cage. There are three layers of intercostal muscles. The external intercostal muscles are most important in respiration. These have fibres that are angled obliquely downward and forward from rib to rib. The contraction of these fibres raises each rib toward the rib above, with the overall effect of raising the rib cage, assisting in inhalation. Accessory muscles of respiration are muscles that assist, but do not play a primary role, in breathing. Use of these while at rest is often interpreted as a sign of respiratory distress.

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