Lecture

Human Tumor Suppressor Genes

Description

This lecture discusses human tumor suppressor genes, focusing on examples such as APC, BRCA1, BRCA2, SMAD4, NF-1, NF-2, and their associated cancer types. It explains the genetic predisposition to cancer, using retinoblastoma as an example to illustrate the role of the RB gene in tumor formation. The lecture also covers the Rb gene's location, function as a tumor suppressor, and the mechanisms of retinoblastoma development through mutations. Additionally, it explores the concepts of sporadic and hereditary retinoblastoma, mitotic recombination, and the inactivation of the Rb gene. The discussion extends to the molecular mechanisms behind retinoblastoma tumor formation, including deletions, mutations, and chromosomal abnormalities.

About this result
This page is automatically generated and may contain information that is not correct, complete, up-to-date, or relevant to your search query. The same applies to every other page on this website. Please make sure to verify the information with EPFL's official sources.

Graph Chatbot

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.