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Explores enzyme activity modulation and small-molecule drug mechanisms, focusing on reversible and irreversible inhibition, progress curves, and covalent bond formation.
Explores the activation, signalling cascades, and regulatory mechanisms of receptor tyrosine kinases, with a focus on disease implications and therapeutic strategies.
Covers the design and analysis of inhibitors for next-generation covalent drugs, focusing on target engagement and the importance of cysteine targeting.
Explores drug targets, particularly nuclear receptors like PPARy and pregnane X receptor, and their impact on endocrine signaling and drug pharmacokinetics.
