Lecture
This lecture by the instructor explores the importance of maintaining protein homeostasis for long-term health, focusing on the manipulation of protein networks to promote healthy ageing. The talk covers topics such as the impact of stress, mutations, and ageing on protein folding, the use of C. elegans as a model for studying proteostasis collapse, and the role of mitochondria in regulating proteostasis. The lecture also delves into how mild mitochondrial stress can extend lifespan and suppress proteostasis collapse. Furthermore, it discusses the activation of a mitochondria-to-HSF1 stress response and the involvement of the PP2A complex in safeguarding the proteome. Overall, the lecture highlights the potential of manipulating protein homeostasis networks to enhance healthy ageing.