Protein Homeostasis Networks: Promoting Healthy Ageing

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Early Events in the Heat Shock Response: Action in the Nucleus

Explores early events in the Heat Shock Response, focusing on Hsf1 regulation, Hsp70 dynamics, and the role of Sis1.

Chaperone-Mediated Disaggregation: Amyloid Fibrils and Hsp70

Explores chaperone-mediated disaggregation of amyloid fibrils by Hsp70 in neurodegenerative diseases.

Proteome Foldedness & Aggregation: Surveying Proteostasis Stress

Explores proteome foldedness, aggregation, and proteostasis stress impact on cell biology and neurodegenerative diseases.

Parkinson's Disease: Genetic Factors

Explores genetic factors in Parkinson's disease, focusing on a-synuclein, Parkin, and PINK1, and their impact on mitochondrial quality control.

Hsp70 Mechanism: Unfolding & Entropic Pulling

Explores Hsp70's role in protein unfolding and entropic pulling, discussing chaperone-driven stabilization and ATP hydrolysis.

Demography and Sustainable Development: Global Perspectives

Explores the relationship between demography and sustainable development, focusing on historical population growth and the implications for future trends.

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Protein Folding: Non-equilibrium Dynamics

Explores protein folding dynamics, focusing on chaperone-assisted non-equilibrium stabilization and its implications for biophysics and evolution.

Protein Folding Dynamics

Explores protein folding dynamics, chaperones, ATP hydrolysis, and DNA folding intricacies within the nucleus.

Cellular Heat Shock Response: Rethinking the Significance

Delves into the cellular heat shock response, emphasizing the absence of a sensor mechanism and the restoration of misfolded protein aggregates.