Mitochondrial Protein Import: Challenges and Mechanisms

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BiP-mediated ER quality control: assists and hurdles

Delves into BiP-mediated ER quality control, addressing protein folding, degradation, and unique challenges in B cell development.

Post-translational regulation of ER proteostasis

Explores the post-translational regulation of ER proteostasis, focusing on BiP chaperone activity, ER stress response, and FICD-mediated AMPylation.

Chaperone-Mediated Disaggregation: Amyloid Fibrils and Hsp70

Explores chaperone-mediated disaggregation of amyloid fibrils by Hsp70 in neurodegenerative diseases.

Protein Folding: Mechanisms and Consequences

Explores protein folding, misfolding consequences, chaperones' role, and ATP importance.

Protein Folding: Chaperone Solutions

Explores chaperones' role in guiding protein folding and preventing misfolding through the functional cycle of Hsp70 and the DnaK chaperone system.

Cellular Heat Shock Response: Rethinking the Significance

Delves into the cellular heat shock response, emphasizing the absence of a sensor mechanism and the restoration of misfolded protein aggregates.

Proteome Foldedness & Aggregation: Surveying Proteostasis Stress

Explores proteome foldedness, aggregation, and proteostasis stress impact on cell biology and neurodegenerative diseases.

Non-refoldability in E. coli Proteome

Delves into non-refoldability in the E. coli proteome, exploring protein folding challenges and implications.

Early Events in the Heat Shock Response: Action in the Nucleus

Explores early events in the Heat Shock Response, focusing on Hsf1 regulation, Hsp70 dynamics, and the role of Sis1.

Proteinopathy Mapping: Connecting Proteotoxicity to Intrinsic Functions

Explores proteinopathy mapping, connecting proteotoxicity to intrinsic functions of aggregation-prone proteins, with a focus on alpha-synuclein and Parkinson's Disease.