Protein Homeostasis: Golgi Apparatus Mechanisms

This lecture by the instructor covers the mechanisms of protein homeostasis at the Golgi apparatus, including organelle-specific quality control mechanisms, Golgi quality control in yeast, and the impact of proteotoxic stress on the Golgi structure. The lecture also delves into induced protein unfolding, degradation of misfolded proteins, and the turnover of lumenal Golgi model proteins. Furthermore, it explores the re-localization of misfolded proteins to the endoplasmic reticulum, retrograde trafficking, and the role of ARF4 in Golgi re-localization. The instructor also discusses Golgi stress at the proteome and transcriptional levels, Golgi structural integrity, and the identification of novel proteins involved in Golgi structural integrity.