Bacterial AAA+ Protease: Activity Control and Toxic Deregulation

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Explores protein homeostasis mechanisms at the Golgi apparatus, including quality control, proteotoxic stress impact, and induced protein unfolding.

Covers protein design fundamentals, including secondary structures, amino acid propensity, loops, and computational methods.

Covers the mechanisms of protein degradation, including the roles of the proteasome and autophagy in regulating protein function.

Explores Hsp70's role in protein unfolding and entropic pulling, discussing chaperone-driven stabilization and ATP hydrolysis.

Explores NMR spectroscopy for protein structure determination and introduces Cryo-EM as a complementary technique with recent advancements.

Explores proteome foldedness, aggregation, and proteostasis stress impact on cell biology and neurodegenerative diseases.

Delves into protein self-assembly, phase transitions, and aggregation mechanisms in diseases like Alzheimer's.

Covers the maturation of proteins and the role of post-translational modifications in their functionality and regulation.

Delves into non-refoldability in the E. coli proteome, exploring protein folding challenges and implications.

Covers protein folding, maturation, degradation, and the implications of misfolding in neurodegenerative diseases.