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This lecture covers the regulation of transcription, genomics, transcriptomics, and epigenomics, emphasizing the dynamic interplay between these fields and their importance in bridging basic and clinical research. It explores the impact of environment, nutrition, lifestyle, pathogens, toxins, genetics, mutations, SNPs, histone modifications, DNA methylation, ncRNA, and epigenetics on gene expression, ultimately shaping phenotypes. The instructor delves into DNA and chromosome structure, gene anatomy, locus control regions, transcription mechanisms, and translation processes, providing a comprehensive understanding of the molecular basis of gene expression.