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This lecture delves into the intricate control and regulation mechanisms of the cardiovascular system, focusing on the microcirculation. It covers topics such as the determinants of ultrafiltration through the endothelium, the impact of respiration on venous return, local and humoral control of blood flow by tissues, the role of vasoactive mediators, and the theory of local autoregulation. Additionally, it explores the central regulation of the cardiovascular system, the role of vascular receptors, and the control of blood pressure. The lecture also discusses the adaptation to exercise, modulation of blood flow, and the distribution of blood flow during physical exertion.