Lecture
DNA Repair Mechanisms
In course
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Description
This lecture covers the mechanisms of DNA repair, focusing on base excision repair (BER), nucleotide excision repair (NER), non-homologous end joining (NHEJ), and homologous recombination (HR). BER and NER require an intact second strand as a template for repair, while NHEJ is used when there is no sister chromatid available. HR is a high-fidelity process that uses a sister chromatid as a repair template. The lecture also discusses the consequences of mutations in DNA repair enzymes and inherited syndromes related to DNA repair defects, such as xeroderma pigmentosum and ataxia telangiectasia.
Instructors (4)
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Official source
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