Catalytic Asymmetric Reactions

This lecture covers the principles and mechanisms of catalytic asymmetric reactions in organic chemistry, focusing on the activation of C-C double bonds and chiral acylation. It discusses the generation of chiral enolates via deprotonation and from enol ethers, as well as the use of Au, Cu, and other catalysts for asymmetric reactions. Various examples of asymmetric reactions using different catalysts are presented, such as ring expansion, polycyclization cascade, and asymmetric Cope rearrangement. The lecture also explores the use of chiral nucleophiles and the synthesis of chiral compounds with high enantioselectivity.