Catalytic Asymmetric Reactions in Organic Chemistry

This lecture covers the principles and mechanisms of catalytic asymmetric reactions in organic chemistry, focusing on topics such as asymmetric electrophilic allylation with Pd, activation of C-C double bonds, and other reactions. The instructor discusses the induction of chirality, ligand structures, and key mechanistic aspects. Various catalytic models and reactions are explored, including desymmetrization, cyclization, and diastereodivergent de-epimerization. Emphasis is placed on ligand steric and electronic properties influencing selectivity. The lecture concludes with a discussion on the generation of chiral enolates using different methods like ketenes, boronates, and carbene. Mechanistic studies and challenges in enamine catalysis are also addressed.