PROTACs: Catalytic Protein Knockdown Strategy

This lecture introduces the concept of Proteolysis Targeting Chimeras (PROTACs), a method that recruits specific protein targets to an E3 ubiquitin ligase for ubiquitination and degradation. The lecture discusses the catalytic behavior of PROTACs, their ability to reduce protein levels significantly at low concentrations, and their potential in tumor xenografts. It also covers the design and testing of PROTACs, including their specificity, mechanism of action, and in vivo experiments. The lecture concludes with a discussion on the ternary complex involved in PROTACs and alternative techniques in drug development.