Explores the design and validation of targeted protein degraders, including PROTACs and molecular glue compounds, emphasizing the importance of proper analyses and validations in TPD research.
Provides an overview of protein post-translational modifications, including phosphorylation, ubiquitination, and acylation.
Explores protein-induced degradation to enhance target druggability and the use of PROTACS in drug development.
Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.
Explores protein modifications through ubiquitination, acylation, and Ras acylation importance.
Explores the druggable proteome, PROTACS strategy, ubiquitin attachment, and drug development paradigms.
Explores protein quality control in membraneless organelles and its implications for diseases.
Delves into the efficacy of covalent drugs in chemical biology, exploring reversible vs. irreversible binders and mechanism-based inactivators.
Explores the application of deep generative models in drug discovery, focusing on designing small molecules and optimizing molecular structures.
Explores protein homeostasis mechanisms at the Golgi apparatus, including quality control, proteotoxic stress impact, and induced protein unfolding.
