Chemical Biology Fundamentals: Covalent Drug Efficacy

In course

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Description

This lecture covers the fundamental concepts of chemical biology, focusing on the efficacy of covalent drugs. Topics include reversible vs. irreversible binders, time-dependent inhibition, nucleophilic amino acids, and mechanism-based inactivators. The instructor presents case studies on PROTACS and HyT as anti-cancer strategies.

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Instructor

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Official source

https://mediaspace.epfl.ch/media/0_qp2b0a5i

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Ontological neighbourhood

Biology

Cell biology: Protein biosynthesis

Chemistry

Chemical reactions: Catalysis

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