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This lecture presents the IR Sense project, focusing on an integrated sensing platform for gases and liquids. The project aims to develop a portable, low-cost sensor using infrared spectroscopy to measure small molecules with high sensitivity and selectivity. The lecture covers the development of optical technologies, the design of interaction cells for gas sensors, and the use of waveguides for liquid measurements. Specific applications discussed include measuring carbon dioxide isotopic ratios and detecting cocaine in saliva. The lecture also highlights achievements in gas sensing and detector technology, emphasizing the potential for multi-gas detection in the future.