Chromosome Anomalies: Trisomy and Uniparental Disomy

This lecture starts with a review of DNA replication and the importance of PCR technology derived from it. The discussion then shifts to microsatellites and their applications in paternity testing, chromosome tracking, and preimplantation diagnosis. The lecture delves into a real case study involving a placental trisomy of chromosome 7, which was not present in the fetus, highlighting the concept of uniparental disomy. The instructor explains the genetic mechanisms behind these anomalies, such as non-disjunction during meiosis, leading to viable placental trisomies but non-viable fetal trisomies. The implications of such genetic variations on prenatal testing and the rarity of certain chromosomal abnormalities are also explored.