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This lecture covers the applications of the Krebs cycle, starting with the conversion of fumaric acid to succinic acid and calculating the enthalpy of formation. The instructor then demonstrates how to calculate the enthalpy of combustion for succinic acid using stoichiometric coefficients and the concept of enthalpies of formation. The lecture concludes with the application of the S cycle to determine the enthalpy of combustion, emphasizing the importance of understanding enthalpy definitions.