Cyclic Peptides and Macrocycles

This lecture explores the characteristics and applications of cyclic peptides and macrocycles, which are molecules with a cyclic architecture and relatively rigid structure. It delves into the comparison with other drug modalities, showcasing the use of macrocycles in the clinic through examples like cyclosporine and caspofungin. The lecture also covers families of macrocycles, including macrolides and peptide macrocycles, highlighting their significance in drug development. Furthermore, it discusses the synthesis of macrocycles in nature and presents examples such as tacrolimus and nisin. The lecture concludes with a focus on the miniaturization of antibodies and the role of bicyclic peptides in targeting specific proteins for therapeutic purposes.