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This lecture covers the regulation of motor activity in the super family of kinesins, the structure and function of dynein, the movement of organelles along microtubules, the assembly of cilia and flagella, and the role of cilia in various biological processes such as mucus clearance, egg transportation, and sensory functions. It also discusses the implications of defects in microtubule-associated structures, such as deafness, renal polycystitis, and obesity.