Covers the mechanisms of protein localization in cells, focusing on synthesis, sorting, and transport pathways involving the endoplasmic reticulum and Golgi apparatus.
Explores membrane protein quality control mechanisms at the ER, focusing on ERAD recognition, retrotranslocation, ubiquitination, and degradation of misfolded proteins.
Explores the evolution and function of protein-repair machineries, emphasizing the role of ATP-fueled unfolding machines in preventing protein aggregation and promoting proper folding.
