This lecture covers the principles and methods of usability testing, focusing on the importance of testing software with future users, applying design principles, and differentiating between low and high fidelity prototyping. The instructor emphasizes the Wizard of Oz method, the key aspects of usability (learnability, efficiency, memorability, errors, and satisfaction), and the process of conducting usability tests with real users. The lecture also discusses the significance of recruiting a diverse sample of users, analyzing results, and convincing designers based on user feedback.