Lecture
This lecture covers the mechanisms ensuring genome duplication fidelity, such as DNA replication, chromosome end duplication, and sister chromatid separation. It also discusses the three models of DNA replication: semiconservative, conservative, and dispersive. Experimental evidence from Meselson and Stahl's famous DNA replication study in E. coli is presented, supporting the semiconservative model proposed by Watson and Crick. The lecture concludes with the implications of the DNA replication models on the structure of the replicated DNA strands.