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This lecture covers the principles of oxidation and disinfection in water treatment, focusing on the use of ozone and chlorine dioxide. It discusses the characteristics, applications, and kinetics of these oxidants, as well as the formation of disinfection by-products. The lecture also explores the importance of advanced oxidation processes and the role of OH radicals. Various case studies and treatment schemes for disinfection are presented, along with the kinetics of micropollutant oxidation. The session concludes with a discussion on the kinetics of disinfection and the factors affecting the inactivation of microorganisms.