Genetic Linkage and Association Studies

This lecture covers the concepts of genetic linkage and association studies, focusing on genetic markers, crossing over, recombination, and polymorphisms. It explains how genes on the same chromosome exhibit linkage and how crossing over during meiosis leads to genetic diversity. The lecture also delves into the history of genetic markers, the importance of linkage disequilibrium in association mapping, and the transition from linkage to genome-wide association studies using single nucleotide polymorphisms (SNPs). It discusses the power of association studies over linkage studies, the role of LD in mapping, and the methodology of genetic association studies, including case-control designs and replication strategies.