This lecture covers the administration and monitoring of medical treatments, focusing on the critical need for drug concentration monitoring in personalized medicine. It discusses classes of medical treatments where monitoring is crucial, the challenges in drug concentration monitoring, the development of in vitro approaches for selecting ligands for drugs, and the use of DNA aptamers for drug detection. The lecture also explores the affordability of analytical systems, microsample analytics in capillaries, and the development of a P2P approach for data storage in medical research.