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This lecture covers the concept of negative feedback in body temperature regulation, focusing on the role of the thermoregulatory center in the hypothalamus, thermoreceptors in the skin, and the mechanisms involved in maintaining core temperature around 37°C. It explains how exposure to cold triggers processes like shivering, decreased blood flow to the skin, and goose bumps. The instructor also discusses how negative feedback mechanisms involving smooth muscles, skeletal muscles, sweat glands, and various glands help regulate body temperature and bring it back to the set point of 37°C.