Tolerance and Autoimmunity: Tolerance

This lecture covers the pathophysiology of tolerance and autoimmune diseases, focusing on central T tolerance through negative selection in the thymus and periphery, as well as central B tolerance in the bone marrow. It also discusses the development of regulatory T cells, autoimmune diseases resulting from central T tolerance break, and peripheral T tolerance mechanisms. The lecture concludes with the importance of self-tolerance and the role of peripheral tolerance in maintaining immune homeostasis.