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This lecture covers the interaction between viruses and bacteria, focusing on how bacteria defend themselves against viral infections through restriction enzymes. It also delves into the immune system's role in distinguishing self from non-self antigens, explaining the importance of the thymus in immune cell education. The concept of autoimmune diseases is explored, highlighting the breakdown of self-tolerance and the implications for health. The lecture concludes with a discussion on immunotherapy for cancer, emphasizing the potential of targeting specific antigens on cancer cells to enhance treatment effectiveness.