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This lecture explores the concepts of genomics, transcriptomics, and epigenomics, emphasizing their dynamic interplay in bridging basic and clinical research in neurodevelopment and brain function. It delves into the influence of environment, nutrition, lifestyle, pathogens, toxins, genetics, mutations, SNPs, histone modifications, DNA methylation, ncRNA, and epigenetics on phenotype. The instructor covers DNA and chromosome structure, gene anatomy, locus control regions, transcription, and translation mechanisms. Additionally, the lecture details the building blocks of genes, including DNA's double helix structure, histones, nucleosomes, and gene anatomy with coding sequences, introns, exons, and regulatory sequences.