Lecture
This lecture explores the role of molecular chaperones in the nucleus and chromatin, focusing on Hsp90 as a key chaperone. Topics include the origin of molecular chaperones, chaperones in different cellular compartments, the interaction of Hsp90 with chromatin, and its implications in cancer. The lecture delves into the evolutionary role of Hsp90 as a capacitor, its genetic and non-genetic interactions, and its function in buffering genetic variation. It also discusses the molecular mechanisms of viral reactivation, the impact of Hsp90 inhibition on gene expression, and the potential of Hsp90 as a therapeutic target in cancer.