This lecture covers the synthesis methods of Transition Metal Dichalcogenides (TMDs) such as exfoliation, epitaxy, and deposition, emphasizing the importance of intercalation and mechanical exfoliation. It also discusses the bottom-up synthesis techniques like Molecular Beam Epitaxy (MBE) and Chemical Vapour Deposition (CVD). The lecture explores strategies for tuning the properties of TMD layers through doping, alloying, and charge transfer. Additionally, it delves into the challenges of epitaxy, strain dilemma, and van der Waals epitaxy. The concepts of passivation, encapsulation, and heterostructures in 2D materials are also explained.